أبحاث تكوين الجسم
FOXO4-DRI
أبحاث تكوين الجسم | 10mg
FOXO4-DRI is a senescence-pathway research peptide studied around FOXO4 and p53 interaction models.
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Get catalog updatesFor laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, mitigate, or prevent disease.
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سياق البحث
ملف بحث FOXO4-DRI
FOXO4-DRI is a cell-penetrating D-retro-inverso peptide developed for research into the interaction between FOXO4 and p53 in senescent cells. Preclinical studies examine whether disrupting that interaction changes p53 localization, apoptosis, senescence markers, tissue function, and age-associated phenotypes in cell and animal models. Its design and evidence base are distinct from broad antioxidant or mitochondrial compounds. FOXO4-DRI is selected for mechanism-specific senescence experiments where cell identity, peptide uptake, controls, and toxicity measurements are carefully defined. The published work remains preclinical; there is no established human clinical evidence, and senolytic findings should not be generalized beyond the original models.
Molecular class
D-retro-inverso FOXO4-derived peptide
Sequence / composition
A cell-penetrating, all-D, retro-inverso construct derived from the FOXO4 p53-interaction region; it is not a native sequence.
Research design note
The retro-inverso architecture is intended to improve protease resistance while preserving a target-facing side-chain pattern.
الآلية المقترحة
A D-retro-inverso cell-penetrating peptide designed to disrupt the FOXO4-p53 interaction in senescent cells. The proposed result is release and nuclear exclusion of p53 followed by preferential apoptosis of cells dependent on FOXO4-mediated survival signaling.
التأثيرات المذكورة في الدراسات
- Cell studies report p53 relocalization and apoptosis in selected senescent-cell models after FOXO4-DRI exposure.
- Aged-mouse studies reported reductions in senescence markers and improvements in selected fitness, fur-density, and renal-function measures.
- Selectivity across senescent cell types, off-target toxicity, delivery, and long-term consequences remain unresolved.
نقاط القياس البحثية الشائعة
FOXO4-p53 binding, p53 localization, apoptosis, senescence-associated beta-galactosidase, p16 and p21, SASP factors, cell viability, tissue function, and off-target toxicity.
الأدلة والقيود
Evidence is limited to mechanistic cell and animal research. No established human clinical efficacy or safety data exist.
External reading
الأدبيات للسياق، وليست إثباتًا للمنتج.
Third-party sources describe their own research materials and methods. They do not validate a specific Azure catalog batch.
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