Endocrine signaling research
HGH
HGH is a somatotropin reference material used in growth hormone receptor, IGF-1 axis, protein-synthesis, and metabolic-signaling research.
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Get catalog updatesFor laboratory research use only. Not for human or veterinary use. Not intended to diagnose, treat, cure, mitigate, or prevent disease.
Store unopened lyophilized material frozen at -20°C or according to the lot CoA/SDS. Protect from light and moisture and minimize temperature cycling.
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CoA per batch; lot reference supplied on fulfillment.
Araştırma bağlamı
HGH araştırma profili
Human growth hormone, or somatotropin, is a full-length protein reference used to study direct growth hormone receptor activation. Research examines JAK2 and STAT signaling, IGF-1 expression, protein and lipid metabolism, cell growth, endocrine feedback, and tissue-specific receptor responses. It differs fundamentally from GHRH analogs and ghrelin-receptor secretagogues, which act upstream to stimulate endogenous GH release in experimental systems. HGH is selected when the project requires the hormone itself as the signaling input or comparator. The extensive clinical and biological literature on regulated pharmaceutical somatropin does not establish the identity, approval status, sterility, or suitability of a separate research-use product.
Molecular class
191-residue human somatotropin
Sequence / composition
A single-chain 191-amino-acid protein with two intramolecular disulfide bonds; it is the full-length hormone rather than a short peptide fragment.
Research design note
It provides direct growth-hormone-receptor input, which is experimentally distinct from GHRH analogs and ghrelin-receptor secretagogues.
Önerilen mekanizma
Binds the growth-hormone receptor, causing receptor dimer rearrangement and activation of JAK2-STAT, MAPK, and PI3K-AKT signaling. It also induces IGF-1 production, especially in the liver, and directly influences lipid, carbohydrate, and protein metabolism.
Çalışmalarda bildirilen etkiler
- Cell and human studies report increased IGF-1, protein synthesis, nitrogen retention, lipolysis, and changes in body composition.
- Growth-hormone signaling can reduce insulin sensitivity and increase glucose, fluid retention, tissue growth, and other dose-related systemic effects.
- Long-term or excessive exposure is associated with edema, arthralgia, carpal-tunnel symptoms, glucose intolerance, and growth-related risks.
Yaygın araştırma sonlanım noktaları
Growth-hormone receptor phosphorylation, JAK2-STAT signaling, IGF-1 and binding proteins, nitrogen balance, protein synthesis, lipolysis, glucose and insulin, fluid balance, and tissue growth.
Kanıtlar ve sınırlamalar
Growth-hormone biology and regulated pharmaceutical use are extensively characterized. A research-use catalog item is not represented as an approved somatropin product.
External reading
Literature for context—not product proof.
Third-party sources describe their own research materials and methods. They do not validate a specific Azure catalog batch.
Support and documentation
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