Dermal and melanocortin research
Melanotan I
Lyophilized dermal or melanocortin research peptide
Melanotan I / afamelanotide is an alpha-MSH analog research peptide tied to melanocortin receptor and pigment biology literature.
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Get catalog updatesNur für Laborforschungszwecke. Nicht für den menschlichen oder veterinärmedizinischen Gebrauch bestimmt. Nicht zur Diagnose, Behandlung, Heilung, Linderung oder Vorbeugung von Krankheiten bestimmt.
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Forschungskontext
Melanotan I Forschungsprofil
Melanotan I is an alpha-melanocyte-stimulating hormone analog closely associated with the afamelanotide research lineage. It is studied primarily through melanocortin 1 receptor activity, cyclic-AMP signaling, melanogenesis, pigment-cell biology, and photobiology models. Compared with Melanotan II, its research profile is more closely centered on pigment pathways and MC1R rather than broad activity across several melanocortin receptors. It is selected when a study requires an alpha-MSH analog for melanocyte or receptor-selectivity work. Literature on approved afamelanotide products and clinical formulations does not establish the identity, approval, sterility, or intended use of a separate research catalog material.
Molecular class
13-residue alpha-MSH analog
Sequence / composition
An acetylated alpha-MSH-derived sequence containing norleucine and D-phenylalanine substitutions.
Research design note
Its construct is generally studied for MC1R-focused pigment biology rather than the broader receptor profile of Melanotan II.
Vorgeschlagener Mechanismus
An alpha-MSH analog that activates melanocortin 1 receptors on melanocytes, stimulating adenylate cyclase, cyclic AMP, MITF-related transcription, tyrosinase activity, and eumelanin production.
In Studien berichtete Effekte
- Cell and human afamelanotide studies report increased melanin production and pigmentation-related measures.
- Clinical studies of regulated afamelanotide formulations report improved phototolerance in specific photosensitivity disorders.
- Pigment changes, nevi monitoring, nausea, headache, and formulation-specific adverse events are relevant observations.
Häufige Forschungsendpunkte
MC1R potency, cyclic AMP, MITF, tyrosinase, melanin content, skin reflectance, phototolerance, pigment distribution, nevus changes, pharmacokinetics, and adverse events.
Evidenz und Grenzen
Mechanistic and regulated-product human evidence exists for afamelanotide. Catalog research material is not represented as an approved implant or cosmetic product.
External reading
Literature for context—not product proof.
Third-party sources describe their own research materials and methods. They do not validate a specific Azure catalog batch.
Support and documentation
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