Cellular-biology research
MOTS-c
Lyophilized mitochondrial and cellular-signaling research material
MOTS-c is a mitochondrial-derived peptide studied in metabolic stress, AMPK-adjacent signaling, glucose metabolism, and cellular adaptation literature.
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Get catalog updatesAlleen voor laboratoriumonderzoek. Niet voor menselijk of diergeneeskundig gebruik. Niet bedoeld voor het diagnosticeren, behandelen, genezen, verzachten of voorkomen van ziekten.
Afgesloten, koud, droog en beschermd tegen hitteschommelingen bewaren. Bevestig productspecifieke opslag bij aankomst.
Verpakt voor stabiliteit tijdens het transport, met bestelondersteuning beschikbaar voor routes bij warm weer.
Batch-linked certificate support is available through the documentation desk.
Onderzoekscontext
MOTS-c onderzoeksprofiel
MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial 12S rRNA and studied as a signal connecting mitochondrial status with cellular metabolism. Research examines metabolic stress, AMPK-adjacent signaling, glucose handling, mitochondrial-to-nuclear communication, gene expression, exercise-related models, and aging-associated markers. It differs from SS-31, which is studied primarily for interaction with the inner mitochondrial membrane and cardiolipin. MOTS-c is selected when a project focuses on signaling and metabolic adaptation rather than direct membrane stabilization. Most mechanistic evidence is preclinical, while human literature includes biomarker and observational work; neither establishes the performance of a specific catalog batch.
Molecular class
16-residue mitochondrial-derived peptide
Sequence / composition
- M
- R
- W
- Q
- E
- M
- G
- Y
- I
- F
- Y
- P
- R
- K
- L
- R
Defined amino-acid chain, shown in standard one-letter notation.
Research design note
Research commonly tests its mitochondrial-to-nuclear signaling context alongside cellular stress and metabolic endpoints.
Voorgesteld mechanisme
A mitochondrial-derived peptide proposed to act as a metabolic stress signal. Reported pathways include AMPK activation, altered folate and purine metabolism, GLUT4-related glucose uptake, and stress-dependent movement to the nucleus where it may influence gene expression.
In studies gerapporteerde effecten
- Cell studies report AMPK-related signaling, improved glucose uptake, stress resistance, and changes in metabolic gene expression.
- Mouse studies report improved insulin sensitivity, exercise capacity, metabolic homeostasis, and resistance to diet- or age-related metabolic stress.
- Human studies are mainly observational or biomarker based and do not establish the effects of administered MOTS-c.
Veelgebruikte onderzoekseindpunten
AMPK phosphorylation, glucose uptake, insulin sensitivity, mitochondrial and nuclear gene expression, exercise capacity, body composition, metabolic stress, and circulating MOTS-c levels.
Bewijs en beperkingen
Mechanistic and animal evidence is promising, but interventional human evidence is limited and pharmacology remains incompletely defined.
External reading
Literature for context—not product proof.
Third-party sources describe their own research materials and methods. They do not validate a specific Azure catalog batch.
Support and documentation
Questions about this product?
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Open the direct COA link on this page. For other batch documents, contact support with the product name and any relevant order or batch reference.
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