Cellular-biology research
MOTS-c
Lyophilized mitochondrial and cellular-signaling research material
MOTS-c is a mitochondrial-derived peptide studied in metabolic stress, AMPK-adjacent signaling, glucose metabolism, and cellular adaptation literature.
This product has an available COA with reported batch details and test results.
Open available COAConfirm an optional email signup to receive a single-use 10% welcome code.
Get catalog updatesSomente para uso em pesquisa laboratorial. Não é para uso humano ou veterinário. Não se destina a diagnosticar, tratar, curar, mitigar ou prevenir doenças.
Mantenha selado, frio, seco e protegido de oscilações de calor. Confirme o armazenamento específico do produto na chegada.
Embalado para estabilidade de trânsito com suporte para pedidos disponível para rotas em clima quente.
Batch-linked certificate support is available through the documentation desk.
Contexto de pesquisa
Perfil de pesquisa de MOTS-c
MOTS-c is a mitochondrial-derived peptide encoded within mitochondrial 12S rRNA and studied as a signal connecting mitochondrial status with cellular metabolism. Research examines metabolic stress, AMPK-adjacent signaling, glucose handling, mitochondrial-to-nuclear communication, gene expression, exercise-related models, and aging-associated markers. It differs from SS-31, which is studied primarily for interaction with the inner mitochondrial membrane and cardiolipin. MOTS-c is selected when a project focuses on signaling and metabolic adaptation rather than direct membrane stabilization. Most mechanistic evidence is preclinical, while human literature includes biomarker and observational work; neither establishes the performance of a specific catalog batch.
Molecular class
16-residue mitochondrial-derived peptide
Sequence / composition
- M
- R
- W
- Q
- E
- M
- G
- Y
- I
- F
- Y
- P
- R
- K
- L
- R
Defined amino-acid chain, shown in standard one-letter notation.
Research design note
Research commonly tests its mitochondrial-to-nuclear signaling context alongside cellular stress and metabolic endpoints.
Mecanismo proposto
A mitochondrial-derived peptide proposed to act as a metabolic stress signal. Reported pathways include AMPK activation, altered folate and purine metabolism, GLUT4-related glucose uptake, and stress-dependent movement to the nucleus where it may influence gene expression.
Efeitos relatados em estudos
- Cell studies report AMPK-related signaling, improved glucose uptake, stress resistance, and changes in metabolic gene expression.
- Mouse studies report improved insulin sensitivity, exercise capacity, metabolic homeostasis, and resistance to diet- or age-related metabolic stress.
- Human studies are mainly observational or biomarker based and do not establish the effects of administered MOTS-c.
Desfechos comuns de pesquisa
AMPK phosphorylation, glucose uptake, insulin sensitivity, mitochondrial and nuclear gene expression, exercise capacity, body composition, metabolic stress, and circulating MOTS-c levels.
Evidências e limitações
Mechanistic and animal evidence is promising, but interventional human evidence is limited and pharmacology remains incompletely defined.
External reading
Literature for context—not product proof.
Third-party sources describe their own research materials and methods. They do not validate a specific Azure catalog batch.
Support and documentation
Questions about this product?
Where can I find product documentation?
Open the direct COA link on this page. For other batch documents, contact support with the product name and any relevant order or batch reference.
How can I compare pack options?
Where multiple pack sizes are available, Azure shows the price per listed vial so you can compare catalog value directly.